منابع مشابه
Reversing Cachexia
Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.
متن کاملFeature CaChexia
Cancer induced cachexia (CIC) is a syndrome of muscle wasting accompanied by anorexia with or without loss of adipose tissue. Underlying CIC is a complex interaction of proinflammatory cytokines that act centrally on the hypothalamus and peripherally to increase catabolism and resting energy expenditure, while decreasing protein synthesis. The presence of CIC is an important prognostic indicato...
متن کاملCancer Cachexia
Cancer anorexia-cachexia (CACS) is defined as a multifactorial syndrome characterized by ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment [1]. Cancer cachexia occurs across a continuum, varying in severity and stage; according to new classification we have pre-cachexia (early clinical signs of c...
متن کاملRunning head: Stress and muscle cachexia Stress and Muscle Cachexia
One of the metabolic hallmarks of sepsis and severe injury is muscle cachexia, mainly reflecting increased protein breakdown, in particular myofibrillar protein breakdown. This review describes recent knowledge regarding the molecular mechanisms of sepsis-induced muscle cachexia. Among different intracellular proteolytic pathways, the energy-ubiquitindependent pathway is particularly important ...
متن کاملCachexia assessment tools.
PURPOSE OF REVIEW Cachexia is a common negative consequence of cancer and is often unrecognized. To assess cachexia, malnutrition assessment tools are used. This review discusses the advantages and disadvantages of the current malnutrition assessment tools and describes the requirements for a comprehensive cachexia assessment instrument and its implication for clinics and research. RECENT FIN...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2019
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-019-0412-9